Phosphorylated Extracellular Signal-regulated Kinases Are Significantly Increased in Malignant Mesothelioma

Extracellular Signal-Regulated Kinases

Cytoplasmic aggregates of phosphorylated extracellular signal-regulated protein kinases in Lewy body diseases.

A better understanding of cellular mechanisms that occur in Parkinson's disease and related Lewy body diseases is essential for development of new therapies. We previously found that 6-hydroxydopamine (6-OHDA) elicits sustained extracellular signal-regulated kinase (ERK) activation that contributes to neuronal cell death in vitro. As subcellular localization of activated kinases affect accessib...

Nociceptor sensitization by extracellular signal-regulated kinases.

Inflammatory pain, characterized by a decrease in mechanical nociceptive threshold (hyperalgesia), arises through actions of inflammatory mediators, many of which sensitize primary afferent nociceptors via G-protein-coupled receptors. Two signaling pathways, one involving protein kinase A (PKA) and one involving the epsilon isozyme of protein kinase C (PKCepsilon), have been implicated in prima...

Expression of activated extracellular signal-regulated kinases 1/2 in malignant melanomas: relationship with clinical outcome.

PURPOSE The purpose of the present work was to analyze the protein expression of activated extracellular signal-regulated kinases 1 and 2 (ERK1/2) in a panel of superficial spreading (SSM) and nodular (NM) primary and metastatic melanomas, and to correlate the expression level with clinicopathological parameters. EXPERIMENTAL DESIGN Expression of activated ERK1/2 was examined by immunohistoch...

Isoform-Specific Roles of Extracellular Signal-Regulated Kinases in Pain

of the Dissertation ............................................................................. ii Acknowledgments .......................................................................................... iv Dedication ........................................................................................................ v Table of